Open AccessReactions Induced by Platelet Transfusions
Author(s) -
V. Kiefel
Publication year - 2008
Publication title -
transfusion medicine and hemotherapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.971
H-Index - 39
eISSN - 1660-3818
pISSN - 1660-3796
DOI - 10.1159/000151350
Subject(s) - medicine , platelet , platelet transfusion , transfusion related acute lung injury , anaphylaxis , intensive care medicine , blood product , surgery , immunology , lung , allergy , pulmonary edema
SUMMARY: Platelet transfusions play a central role in therapeutic regimens for patients with hematologic/oncologic diseases who develop severe thrombocytopenia either in the course of their disease or following cytostatic therapy. Like other blood components, platelet transfusions have achieved a high degree of safety as far as transmission of viral diseases is concerned. However, transfusion of platelet concentrates is accompanied by a high frequency of febrile and anaphylactoid reactions. In rare cases, recipients of platelet concentrates are threatened by severe reactions as septic complications due to bacterial contamination of platelet concentrates, transfusion-related acute lung injury and severe anaphylactic episodes.