Open AccessMonkeypox Virus as a Source of Whitepox Viruses
Author(s) -
С. С. Маренникова,
E. M. Shelukhina,
N N Mal'tseva,
G R Matsevich
Publication year - 1979
Publication title -
intervirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.641
H-Index - 61
eISSN - 1423-0100
pISSN - 0300-5526
DOI - 10.1159/000149055
Subject(s) - monkeypox , virology , virus , biology , population , cloning (programming) , hemagglutination , white (mutation) , poxviridae , vaccinia , genetics , medicine , gene , environmental health , computer science , programming language , recombinant dna
Monkeypox virus cloning and isolation of the so-called 'white' clones from white pocks which this virus forms on the chorioallantoic membrane (CAM) were carried out. The isolated clones were stable and differed considerably from the parental strain. By their properties, they were identical to whitepox viruses formerly isolated from wildlife monkeys and rodents in Equatorial Africa. Besides stable 'white' clones, a number of virus cultures in the process of cloning were obtained which differed in quantitative content of virions, forming on CAM white pocks and pocks with hemorrhages. It appeared that the properties of the viral population as a whole (reaction type on rabbit skin, hemagglutination activity, etc.) depended on the rate of virions produced with different characteristics.