Power of Genetic Association Studies in the Presence of Linkage Disequilibrium and Allelic Heterogeneity | Zendy

Sheila Fisher | Zendy; Cathryn M. Lewis | Zendy

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Power of Genetic Association Studies in the Presence of Linkage Disequilibrium and Allelic Heterogeneity

Author(s) -

Sheila Fisher,

Cathryn M. Lewis

Publication year - 2008

Publication title -

human heredity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.423

H-Index - 62

eISSN - 1423-0062

pISSN - 0001-5652

DOI - 10.1159/000143404

Subject(s) - genetics , linkage disequilibrium , biology , genetic association , allele , sample size determination , tag snp , genotyping , allelic heterogeneity , genetic heterogeneity , single nucleotide polymorphism , genotype , haplotype , statistics , phenotype , gene , mathematics

The calculation of the power and sample size required for association studies is essential, particularly for follow-up of genome-wide association studies, where much genotyping is required to replicate the original finding and identify the true disease susceptibility mutation.

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