Open AccessPower of Genetic Association Studies in the Presence of Linkage Disequilibrium and Allelic Heterogeneity
Author(s) -
Sheila Fisher,
Cathryn M. Lewis
Publication year - 2008
Publication title -
human heredity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.423
H-Index - 62
eISSN - 1423-0062
pISSN - 0001-5652
DOI - 10.1159/000143404
Subject(s) - genetics , linkage disequilibrium , biology , genetic association , allele , sample size determination , tag snp , genotyping , allelic heterogeneity , genetic heterogeneity , single nucleotide polymorphism , genotype , haplotype , statistics , phenotype , gene , mathematics
The calculation of the power and sample size required for association studies is essential, particularly for follow-up of genome-wide association studies, where much genotyping is required to replicate the original finding and identify the true disease susceptibility mutation.