A Distinct Population of Tubular Cells in the Distal S3 Segment Contributes to S3 Segment Regeneration in Rats following Acute Renal Failure Induced by Uranyl Acetate | Zendy

Masanori Sakakima | Zendy; Yoshihide Fujigaki | Zendy; Tatsuo Yamamoto | Zendy; Akira Hishida | Zendy

Open Access

A Distinct Population of Tubular Cells in the Distal S3 Segment Contributes to S3 Segment Regeneration in Rats following Acute Renal Failure Induced by Uranyl Acetate

Author(s) -

Masanori Sakakima,

Yoshihide Fujigaki,

Tatsuo Yamamoto,

Akira Hishida

Publication year - 2008

Publication title -

nephron experimental nephrology

Language(s) - English

Resource type - Journals

ISSN - 1660-2129

DOI - 10.1159/000142100

Subject(s) - bromodeoxyuridine , thymidine , population , regeneration (biology) , uranyl acetate , chemistry , medicine , cell growth , endocrinology , microbiology and biotechnology , biology , pathology , in vitro , biochemistry , staining , environmental health

We previously reported that early regenerating cells found at the distal area of the S3 segment of the nephron (designated as target cells) were label-retaining cells in uranyl acetate (UA)-induced acute renal failure (ARF) in rats. In this study, we examined the contribution of these target cells to S3 segment repair after UA treatment. We also discriminated target cells from bromodeoxyuridine (BrdU)-label-retaining cells labeled under normal conditions and examined their capacity to proliferate following a second insult and their resistance to 5-fluorouracil (5-FU).

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