z-logo
open-access-imgOpen Access
Estrogen Receptor-α Variants Increase Risk of Alzheimer’s Disease in Women with Down Syndrome
Author(s) -
Nicole Schupf,
Joseph H. Lee,
Michelle Wei,
Deborah Pang,
Constance Chace,
Rong Cheng,
Warren B. Zigman,
Benjamin Tycko,
Wayne Silverman
Publication year - 2008
Publication title -
dementia and geriatric cognitive disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.026
H-Index - 110
eISSN - 1421-9824
pISSN - 1420-8008
DOI - 10.1159/000126495
Subject(s) - estrogen receptor alpha , dementia , estrogen , allele , estrogen receptor , alzheimer's disease , medicine , genotype , endocrinology , single nucleotide polymorphism , apolipoprotein e , biology , cognitive decline , disease , genetics , gene , breast cancer , cancer
Genetic variants that affect estrogen activity may influence the risk of Alzheimer's disease (AD). Two tightly linked polymorphisms (PvuII and XbaI) in the first intron of estrogen receptor 1 (ESR1), the gene for ER-alpha, have been reported to influence estrogen receptor expression and may influence the risk of AD.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here