Estrogen Receptor-α Variants Increase Risk of Alzheimer’s Disease in Women with Down Syndrome | Zendy

Nicole Schupf | Zendy; Joseph H. Lee | Zendy; Michelle Wei | Zendy; Deborah Pang | Zendy; Constance Chace | Zendy; Rong Cheng | Zendy; Warren B. Zigman | Zendy; Benjamin Tycko | Zendy; Wayne Silverman | Zendy

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Estrogen Receptor-α Variants Increase Risk of Alzheimer’s Disease in Women with Down Syndrome

Author(s) -

Nicole Schupf,

Joseph H. Lee,

Michelle Wei,

Deborah Pang,

Constance Chace,

Rong Cheng,

Warren B. Zigman,

Benjamin Tycko,

Wayne Silverman

Publication year - 2008

Publication title -

dementia and geriatric cognitive disorders

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.026

H-Index - 110

eISSN - 1421-9824

pISSN - 1420-8008

DOI - 10.1159/000126495

Subject(s) - estrogen receptor alpha , dementia , estrogen , allele , estrogen receptor , alzheimer's disease , medicine , genotype , endocrinology , single nucleotide polymorphism , apolipoprotein e , biology , cognitive decline , disease , genetics , breast cancer , gene , cancer

Genetic variants that affect estrogen activity may influence the risk of Alzheimer's disease (AD). Two tightly linked polymorphisms (PvuII and XbaI) in the first intron of estrogen receptor 1 (ESR1), the gene for ER-alpha, have been reported to influence estrogen receptor expression and may influence the risk of AD.

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