Effect of Adenosine on Membrane Potential and Ca2+ in Juxtaglomerular Cells | Zendy

Julia Kristina Laske-Ernst | Zendy; Alexander Stehle | Zendy; Volker Vallon | Zendy; Ulrich Quast | Zendy; Ulrich Ruß | Zendy

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Effect of Adenosine on Membrane Potential and Ca<sup>2+</sup> in Juxtaglomerular Cells

Author(s) -

Julia Kristina Laske-Ernst,

Alexander Stehle,

Volker Vallon,

Ulrich Quast,

Ulrich Ruß

Publication year - 2008

Publication title -

kidney and blood pressure research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.806

H-Index - 51

eISSN - 1423-0143

pISSN - 1420-4096

DOI - 10.1159/000119712

Subject(s) - adenosine , medicine , endocrinology , chemistry , angiotensin ii , afferent arterioles , stimulation , receptor , biology

Renin is mainly secreted from the juxtaglomerular cells (JGC) in the kidney situated in the afferent arteriole close to the vessel pole. Angiotensin II (ANG II) and adenosine inhibit renin secretion and synergistically constrict the afferent arteriole. ANG II depolarises JGC and increases the cytoplasmic free Ca2+ concentration [Ca2+]i. The responses of JGC to adenosine are less known.

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