Open AccessDecreased Expression of Slc26a4 (Pendrin) and Slc26a7 in the Kidneys of Carbonic Anhydrase II-Deficient Mice
Author(s) -
Xuming Sun,
Manoocher Soleimani,
Snežana Petrović
Publication year - 2008
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000113751
Subject(s) - pendrin , immunolabeling , carbonic anhydrase ii , carbonic anhydrase , bicarbonate , chemistry , microbiology and biotechnology , intercalated cell , medicine , endocrinology , kidney , biology , transporter , biochemistry , immunohistochemistry , gene , enzyme
Intercalated cells (ICs) of the kidney collecting duct are rich in carbonic anhydrase II (CAII), which facilitates proton and bicarbonate transport. Bicarbonate secretion is mediated via Pendrin (Slc26a4), which is expressed on the apical membrane of B-ICs and nonA-nonB ICs in the cortical collecting ducts (CCD). Bicarbonate absorption is mediated via anion exchanger 1 (AE1-Slc4a1) in the CCD and via AE1 and possibly Slc26a7 in the OMCD. Both exchangers are expressed on the basolateral membrane of A-ICs. The aim of this study was to examine the expression of pendrin, Slc26a7, and AE1 in the kidneys of CAII-deficient (CAR2-null) mice.