Open AccessTissue Inhibitor of Matrix Metalloproteinase-1 in Norepinephrine-Induced Remodeling of the Mouse Heart
Author(s) -
Henning Meier,
Jörg Bullinger,
Alexander Deten,
Grit Marx,
Steffen Rabald,
HeinzGerd Zimmer,
Wilfried Briest
Publication year - 2007
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000110442
Subject(s) - medicine , endocrinology , matrix metalloproteinase , ventricle , contractility , atrial natriuretic peptide , chemistry , fibrosis , norepinephrine , dopamine
Matrix metalloproteinases (MMPs) play an important role in myocardial remodeling. Their activity is regulated by the tissue inhibitors of metalloproteinases (TIMPs). The present study analyzed the contribution of changes in functional and molecular parameters to early cardiac remodeling in mice hearts. The role that TIMPs might play in this process was specially acknowledged.