Open AccessBlockade of Estrogen Receptors Decreases CNS and Pituitary Prostaglandin Synthase Expression in Fetal Sheep
Author(s) -
C Schaub,
Maureen KellerWood,
Charles E. Wood
Publication year - 2007
Publication title -
neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.493
H-Index - 101
eISSN - 1423-0194
pISSN - 0028-3835
DOI - 10.1159/000109664
Subject(s) - medicine , endocrinology , fetus , estrogen , hypothalamus , prostaglandin , receptor , biology , pregnancy , genetics
Both prostaglandin E2 (PGE2) and estradiol stimulate fetal ACTH secretion and augment fetal ACTH responses to stress. We have reported that estradiol increases prostaglandin endoperoxide synthase-2 (PGHS-2), and we have proposed that there is a positive feedback relationship between estrogen and fetal hypothalamus-pituitary-adrenal (HPA) axis activity that is dependent upon PGHS activity in the fetal brain. The present study was designed to test the hypothesis that blockade of estrogen receptors in the fetal brain decrease PGHS-2 expression and reduces fetal HPA axis activity.