The Protective Effects of N-n-butyl Haloperidol Iodide on Myocardial Ischemia-Reperfusion Injury in Rats by Inhibiting Egr-1 Overexpression | Zendy

Yanmei Zhang | Zendy; Ganggang Shi | Zendy; Jinhong Zheng | Zendy; Tang Zhao | Zendy; Ping Gao | Zendy; Yanqiu Lv | Zendy; Fuxiao Guo | Zendy; Qiangyong Jia | Zendy

Open Access

The Protective Effects of <i>N</i>-n-butyl Haloperidol Iodide on Myocardial Ischemia-Reperfusion Injury in Rats by Inhibiting Egr-1 Overexpression

Author(s) -

Yanmei Zhang,

Ganggang Shi,

Jinhong Zheng,

Tang Zhao,

Ping Gao,

Yanqiu Lv,

Fuxiao Guo,

Qiangyong Jia

Publication year - 2007

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000107547

Subject(s) - western blot , troponin i , myeloperoxidase , downregulation and upregulation , reperfusion injury , tumor necrosis factor alpha , medicine , ischemia , pharmacology , chemistry , inflammation , endocrinology , myocardial infarction , biochemistry , gene

Our previous studies have shown that N-n-butyl haloperidol iodide (F(2)) can antagonize myocardial ischemia/reperfusion (I/R) injury by blocking intracellular Ca(2+) overload. The present study is to test the hypothesis that the protective effects of F(2) on myocardial I/R injury is mediated by downregulating Egr-1 expression.

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