Open AccessThe Protective Effects of <i>N</i>-n-butyl Haloperidol Iodide on Myocardial Ischemia-Reperfusion Injury in Rats by Inhibiting Egr-1 Overexpression
Author(s) -
Yanmei Zhang,
GuoMing Shi,
Jinhong Zheng,
Tong Zhao,
Ping Gao,
Yanqiu Lv,
Fuxiao Guo,
Qiang-Yong Jia
Publication year - 2007
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000107547
Subject(s) - western blot , troponin i , myeloperoxidase , downregulation and upregulation , reperfusion injury , tumor necrosis factor alpha , medicine , ischemia , pharmacology , chemistry , inflammation , endocrinology , myocardial infarction , biochemistry , gene
Our previous studies have shown that N-n-butyl haloperidol iodide (F(2)) can antagonize myocardial ischemia/reperfusion (I/R) injury by blocking intracellular Ca(2+) overload. The present study is to test the hypothesis that the protective effects of F(2) on myocardial I/R injury is mediated by downregulating Egr-1 expression.