Open AccessAnti-Apoptotic Effects of Arachidonic Acid and Prostaglandin E<sub>2</sub> in Pancreatic β-Cells
Author(s) -
Alexandros Papadimitriou,
Aileen King,
Peter M. Jones,
Shanta J. Persaud
Publication year - 2007
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000107544
Subject(s) - apoptosis , arachidonic acid , metabolite , prostaglandin , prostaglandin e , chemistry , endocrinology , medicine , beta cell , prostaglandin e2 , islet , cyclooxygenase , biology , biochemistry , insulin , enzyme
The polyunsaturated fatty acid arachidonic acid (AA) has been implicated in beta-cell defence mechanisms and prostaglandin (PG) products of cyclooxygenase (COX) 2 action confer resistance to alloxan-induced apoptosis in insulin-secreting RIN cells. We have now investigated the anti-apoptotic effects of AA and its metabolite, PGE(2), in the MIN6 mouse insulin-secreting beta-cell line and mouse islets.