Anti-Apoptotic Effects of Arachidonic Acid and Prostaglandin E2 in Pancreatic β-Cells | Zendy

Alexandros Papadimitriou | Zendy; Aileen King | Zendy; Peter M. Jones | Zendy; Shanta J. Persaud | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Anti-Apoptotic Effects of Arachidonic Acid and Prostaglandin E<sub>2</sub> in Pancreatic β-Cells

Author(s) -

Alexandros Papadimitriou,

Aileen King,

Peter M. Jones,

Shanta J. Persaud

Publication year - 2007

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000107544

Subject(s) - apoptosis , arachidonic acid , metabolite , prostaglandin , prostaglandin e , chemistry , endocrinology , medicine , beta cell , prostaglandin e2 , islet , cyclooxygenase , biology , biochemistry , insulin , enzyme

The polyunsaturated fatty acid arachidonic acid (AA) has been implicated in beta-cell defence mechanisms and prostaglandin (PG) products of cyclooxygenase (COX) 2 action confer resistance to alloxan-induced apoptosis in insulin-secreting RIN cells. We have now investigated the anti-apoptotic effects of AA and its metabolite, PGE(2), in the MIN6 mouse insulin-secreting beta-cell line and mouse islets.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research