Differential Role of TNF Receptors in Cellular Trafficking of Intact TNF | Zendy

Weihong Pan | Zendy; Hong Tu | Zendy; Chuanhui Yu | Zendy; Hung Hsuchou | Zendy; Yijun Yang | Zendy; Abba J. Kastin | Zendy

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Differential Role of TNF Receptors in Cellular Trafficking of Intact TNF

Author(s) -

Weihong Pan,

Hong Tu,

Chuanhui Yu,

Hung Hsuchou,

Yijun Yang,

Abba J. Kastin

Publication year - 2007

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000107539

Subject(s) - transcytosis , endocytosis , receptor , microbiology and biotechnology , tumor necrosis factor alpha , chemistry , hek 293 cells , exocytosis , cell , biophysics , biology , biochemistry , immunology , secretion

Although ligand signaling and degradation within the cell have received much attention, few studies have quantified the role of receptors on the transcytosis of ligand into and out of the cell in intact form. Accordingly, we determined the differential role of the two receptors for tumor necrosis factor alpha (TNFR1, TNFR2) on cellular transcytosis.

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