Open AccessHelicobacter pylori-Associated Gastritis Is Related to babA2 Expression without Heterogeneity of the 3′ Region of the cagA Genotype in Gastric Biopsy Specimens
Author(s) -
Xue Fei Xie,
Masanori Ito,
Masaharu Sumii,
S Tanaka,
Masaharu Yoshihara,
Kazuaki Chayama
Publication year - 2007
Publication title -
pathobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 53
eISSN - 1423-0291
pISSN - 1015-2008
DOI - 10.1159/000105814
Subject(s) - caga , helicobacter pylori , gastritis , bacterial adhesin , antrum , intestinal metaplasia , medicine , biology , gastroenterology , gene , stomach , virulence , genetics
Cytotoxin-associated gene A (cagA) is the major virulence factor of Helicobacter pylori strains and affects the clinical outcome of patients. Blood group antigen binding adhesin (BabA) helps the strains adhere to the epithelial cell layer and is the most important adhesin of H. pylori.