Modification in the von Hippel-Lindau Protein Is Involved in the Progression of Experimentally Induced Rat Glomerulonephritis | Zendy

Yoshihiro Kudo | Zendy; Yoshihiko Kakinuma | Zendy; Mitsuko Iguchi | Zendy; Takayuki Sato | Zendy; Tetsuro Sugiura | Zendy; Mutsuo Furihata | Zendy; Taro Shuin | Zendy

Open Access

Modification in the von Hippel-Lindau Protein Is Involved in the Progression of Experimentally Induced Rat Glomerulonephritis

Author(s) -

Yoshihiro Kudo,

Yoshihiko Kakinuma,

Mitsuko Iguchi,

Takayuki Sato,

Tetsuro Sugiura,

Mutsuo Furihata,

Taro Shuin

Publication year - 2007

Publication title -

nephron experimental nephrology

Language(s) - English

Resource type - Journals

ISSN - 1660-2129

DOI - 10.1159/000103022

Subject(s) - pathogenesis , podocyte , thrombin , endocrinology , medicine , kidney , western blot , inducer , immunohistochemistry , glomerulonephritis , angiotensin ii , blot , cancer research , biology , receptor , proteinuria , gene , platelet , biochemistry

We previously demonstrated that angiotensin II (AII) combined with Habu snake venom (HV) induces glomerulonephritis (GN) in rats, with lesions being restricted to the glomeruli 2 days after the administration of both reagents, but the mechanisms inducing GN are unclear. We also indicated a role for hypoxia-inducible factor (HIF)-1alpha in attenuating the progression of GN. However, a role of the von Hippel-Lindau (VHL) protein in GN and mechanisms by which HV regulates the pathogenesis of GN remains unclear.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research