Open AccessKCNE Beta Subunits Determine pH Sensitivity of KCNQ1 Potassium Channels
Author(s) -
Dirk Heitzmann,
Viktoria Koren,
Michael Wagner,
Christina Sterner,
Markus Reichold,
Ines Tegtmeier,
Tilmann Volk,
Richard Warth
Publication year - 2007
Publication title -
cellular physiology and biochemistry
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000099189
Subject(s) - homomeric , chemistry , potassium channel , biophysics , repolarization , extracellular , ion channel , myocyte , patch clamp , cardiac action potential , microbiology and biotechnology , apamin , transfection , biochemistry , biology , electrophysiology , protein subunit , neuroscience , receptor , gene
Heteromeric KCNEx/KCNQ1 (=KvLQT1, Kv7.1) K(+) channels are important for repolarization of cardiac myocytes, endolymph secretion in the inner ear, gastric acid secretion, and transport across epithelia. They are modulated by pH in a complex way: homomeric KCNQ1 is inhibited by external acidification (low pH(e)); KCNE2/KCNQ1 is activated; and for KCNE1/KCNQ1, variable effects have been reported.