KCNE Beta Subunits Determine pH Sensitivity of KCNQ1 Potassium Channels | Zendy

Dirk Heitzmann | Zendy; Viktoria Koren | Zendy; Michael Wagner | Zendy; Christina Sterner | Zendy; Markus Reichold | Zendy; Ines Tegtmeier | Zendy; Tilmann Volk | Zendy; Richard Warth | Zendy

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KCNE Beta Subunits Determine pH Sensitivity of KCNQ1 Potassium Channels

Author(s) -

Dirk Heitzmann,

Viktoria Koren,

Michael Wagner,

Christina Sterner,

Markus Reichold,

Ines Tegtmeier,

Tilmann Volk,

Richard Warth

Publication year - 2007

Publication title -

cellular physiology and biochemistry

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000099189

Subject(s) - homomeric , chemistry , potassium channel , biophysics , repolarization , extracellular , ion channel , myocyte , patch clamp , cardiac action potential , microbiology and biotechnology , apamin , transfection , biochemistry , biology , electrophysiology , protein subunit , neuroscience , receptor , gene

Heteromeric KCNEx/KCNQ1 (=KvLQT1, Kv7.1) K(+) channels are important for repolarization of cardiac myocytes, endolymph secretion in the inner ear, gastric acid secretion, and transport across epithelia. They are modulated by pH in a complex way: homomeric KCNQ1 is inhibited by external acidification (low pH(e)); KCNE2/KCNQ1 is activated; and for KCNE1/KCNQ1, variable effects have been reported.

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