Open AccessNeural Differentiation of Embryonic Stem Cells is Induced by Signalling from Non-Neural Niche Cells
Author(s) -
Kristine Bentz,
Marek Molcanyi,
Simone Heß,
Annette Schneider,
Juergen Hescheler,
Edmund Neugebauer,
Ute Schaefer
Publication year - 2006
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000097674
Subject(s) - embryonic stem cell , microbiology and biotechnology , biology , neurosphere , astrocyte , neural stem cell , endothelial stem cell , stem cell , cellular differentiation , nestin , progenitor cell , neuroepithelial cell , lineage markers , adult stem cell , neuroscience , in vitro , central nervous system , genetics , gene
Embryonic stem cell (ESC) transplantation offers new therapeutic strategies for neurodegenerative diseases and injury. However, the mechanisms underlying integration and differentiation of engrafted ESCs are poorly understood. This study elucidates the influence of exogenous signals on ESC differentiation using in vitro modelling of non-stem/stem cell interactions.