Open AccessP2Y Receptors Activate MAPK/ERK Through a Pathway Involving PI3K/PDK1/PKC-ζ in Human Vein Endothelial Cells
Author(s) -
Mercedes Montiel,
Blanca Esther,
Eugenio Jiménez
Publication year - 2006
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000095180
Subject(s) - mapk/erk pathway , wortmannin , microbiology and biotechnology , pertussis toxin , phosphorylation , protein kinase c , kinase , protein kinase a , mapk cascade , p2y receptor , biology , chemistry , signal transduction , protein kinase b , extracellular , purinergic receptor , g protein
In this study we investigated the effects of P2 receptors in the regulation of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) in human umbilical vein endothelial cells (HUVEC).