Open AccessActivation of β<sub>3</sub> Adrenergic Receptor Decreases DNA synthesis in Human Skin Fibroblasts Via Cyclic GMP/Nitric Oxide Pathway
Author(s) -
César Furlán,
Leonor SterinBorda,
Enri Borda
Publication year - 2005
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000089843
Subject(s) - dna synthesis , fibroblast , nitric oxide , receptor , signal transduction , nitric oxide synthase , agonist , soluble guanylyl cyclase , human skin , radioligand , chemistry , medicine , microbiology and biotechnology , endocrinology , biology , in vitro , biochemistry , guanylate cyclase , genetics
Evidences have shown that beta1 and beta2 adrenoceptors co-exist in human fibroblasts, but it is not yet clear the functional expression of beta3 adrenoceptor in these cells. The aim of this study was to investigate the expression and biological effect of beta3 adrenoceptor activation in human skin fibroblast and the different signaling pathways involved in its effect.