Open AccessCrosstalk Between Mesangial and Endothelial Cells: Angiotensin II Down-Regulates Endothelin-Converting Enzyme 1
Author(s) -
Susana LópezOngil,
M-Luisa Díez-Marqués,
Mercedes Griera,
Manuel Rodrı́guez-Puyol,
Diego Rodríguez–Puyol
Publication year - 2005
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000083646
Subject(s) - losartan , endothelin 1 , umbilical vein , angiotensin ii , endocrinology , medicine , endothelin receptor , human umbilical vein endothelial cell , renin–angiotensin system , mesangial cell , endothelins , chemistry , endothelial stem cell , crosstalk , bradykinin , kidney , microbiology and biotechnology , biology , receptor , biochemistry , in vitro , blood pressure , physics , optics
Since mesangial and endothelial cells interact in the kidney, the present experiments were designed to analyze the ability of human mesangial cells (HMC) to modulate endothelin-1 (ET-1) synthesis by human umbilical vein endothelial cells (HuVEC).