Open AccessProtein Phosphatase 2A Regulatory Subunit Bβ Promotes MAP Kinase-mediated Migration of A431 Cells
Author(s) -
Natsuko Nakada,
Kensuke Kuroda,
Ei Kawahara
Publication year - 2005
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000083635
Subject(s) - protein phosphatase 2 , protein subunit , phosphatase , microbiology and biotechnology , kinase , protein phosphatase 1 , chemistry , phosphorylation , biology , biochemistry , gene
Phosphatases are involved in regulation of MAP kinase (MAPK). A431 cells migrate on collagen after EGF stimulation using MAPK. To clarify the involvement of PP2A in this MAPK-dependent migration, the expression of an isoform of the B regulatory subunit was inhibited.