Thrombophilia in young women candidate to the pill: reasons for and against screening | Zendy

Benilde Cosmi | Zendy; S Coccheri | Zendy

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Thrombophilia in young women candidate to the pill: reasons for and against screening

Author(s) -

Benilde Cosmi,

S Coccheri

Publication year - 2002

Publication title -

pathophysiology of haemostasis and thrombosis

Language(s) - English

Resource type - Journals

eISSN - 1424-8840

pISSN - 1424-8832

DOI - 10.1159/000073588

Subject(s) - medicine , thrombophilia , pill , genetic testing , venous thromboembolism , desogestrel , psychosocial , family history , intensive care medicine , gynecology , obstetrics , family planning , thrombosis , surgery , population , psychiatry , pharmacology , environmental health , research methodology

Screening for thrombophilia in women candidate to the pill is still a matter of debate. Oral contraceptives may trigger venous thromboembolic events in carriers of common inherited thrombophilic defects. General screening is not cost-effective from an epidemiological point of view if the objective is to prevent death due to venous thromboembolism during oral contraception (OC). However, clinicians deal with single patients and personal and/or family history for venous thromboembolism have limited value for identifying those women at risk of VTE complications during OC. A pharmacogenetics approach in prescribing OC on the basis of each woman's genetic make-up could increase drug safety. A proper evaluation of the cost-effectiveness, the medical, psychosocial and legal consequences is needed before general screening with genetic testing for inherited thrombophilia can be recommended before OC.

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