Open AccessInterleukin-8 and Tumor Necrosis Factor-Alpha Are Increased in Minimal Change Disease but Do Not Alter Albumin Permeability
Author(s) -
Min Hyun Cho,
Hwan Seok Lee,
Byung-Ho Choe,
Soonhak Kwon,
Ki Young Chung,
Ja Hoon Koo,
Cheol Woo Ko
Publication year - 2003
Publication title -
american journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 85
eISSN - 1421-9670
pISSN - 0250-8095
DOI - 10.1159/000072065
Subject(s) - tumor necrosis factor alpha , medicine , endocrinology , minimal change disease , pathogenesis , nephrotic syndrome , albumin , nephrosis , cytokine , glomerulonephritis , focal segmental glomerulosclerosis , kidney
Minimal change disease (MCD) is the most common primary nephrotic syndrome in children. Some suggested that interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) are involved in the pathogenesis of MCD. This study was done to see changes of plasma and urinary IL-8, TNF-alpha, and their effects on determination of permeability of glomerular basement membrane (BM) contributed by heparan sulfate proteoglycan (HSPG).