Interleukin-8 and Tumor Necrosis Factor-Alpha Are Increased in Minimal Change Disease but Do Not Alter Albumin Permeability | Zendy

Min Hyun Cho | Zendy; Hwan Seok Lee | Zendy; ByungHo Choe | Zendy; Soonhak Kwon | Zendy; Ki Yong Chung | Zendy; Ja Hoon Koo | Zendy; Cheol Woo Ko | Zendy

Open Access

Interleukin-8 and Tumor Necrosis Factor-Alpha Are Increased in Minimal Change Disease but Do Not Alter Albumin Permeability

Author(s) -

Min Hyun Cho,

Hwan Seok Lee,

ByungHo Choe,

Soonhak Kwon,

Ki Yong Chung,

Ja Hoon Koo,

Cheol Woo Ko

Publication year - 2003

Publication title -

american journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 85

eISSN - 1421-9670

pISSN - 0250-8095

DOI - 10.1159/000072065

Subject(s) - tumor necrosis factor alpha , medicine , endocrinology , minimal change disease , pathogenesis , nephrotic syndrome , albumin , nephrosis , cytokine , glomerulonephritis , focal segmental glomerulosclerosis , kidney

Minimal change disease (MCD) is the most common primary nephrotic syndrome in children. Some suggested that interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) are involved in the pathogenesis of MCD. This study was done to see changes of plasma and urinary IL-8, TNF-alpha, and their effects on determination of permeability of glomerular basement membrane (BM) contributed by heparan sulfate proteoglycan (HSPG).

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