Open AccessCurrent Perspective on Antithrombin Drugs
Author(s) -
John L. McGregor
Publication year - 2002
Publication title -
pathophysiology of haemostasis and thrombosis
Language(s) - Uncategorized
Resource type - Journals
eISSN - 1424-8840
pISSN - 1424-8832
DOI - 10.1159/000069106
Subject(s) - thrombin , proinflammatory cytokine , thrombomodulin , tissue factor , coagulation , serine protease , inflammation , antithrombin , protein c , endothelium , medicine , thrombosis , kidney , fibrin , immunology , protease , chemistry , heparin , biochemistry , enzyme , platelet
Thrombin is a multifunctional serine protease, which is involved in blood coagulation and thrombosis, inflammation and wound repair in tissue injury. Its role in the amelioration of inflammatory tissue injury has been investigated. Protease-activated cell surface receptors (PARs) when activated by thrombin result in the production of proinflammatory mediators. In the kidney, these PARs are expressed on the glomerular epithelium and the vascular endothelium. The significant impact of thrombin inhibition on the development of crescentic glomerular nephritis is discussed.