Differential Expression of Mcp-1 and Its Receptor CCR2 in Glucose Primed Human Mesangial Cells | Zendy

Ulf Janssen | Zendy; Eveline Sowa | Zendy; Petra Marchand | Zendy; Jürgen Floege | Zendy; Aled O. Phillips | Zendy; Heinfried H. Radeke | Zendy

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Differential Expression of Mcp-1 and Its Receptor CCR2 in Glucose Primed Human Mesangial Cells

Author(s) -

Ulf Janssen,

Eveline Sowa,

Petra Marchand,

Jürgen Floege,

Aled O. Phillips,

Heinfried H. Radeke

Publication year - 2002

Publication title -

the nephron journals/nephron journals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.951

H-Index - 72

eISSN - 2235-3186

pISSN - 1660-8151

DOI - 10.1159/000065448

Subject(s) - ccr2 , medicine , endocrinology , monocyte , proinflammatory cytokine , chemokine , receptor , mesangial cell , chemokine receptor , biology , inflammation , kidney

Glomerular mononuclear cell infiltration is associated with the development of a diffuse glomerulosclerosis in patients with diabetic nephropathy. Monocyte chemoattractant protein-1 (MCP-1) plays an important role in the recruitment and accumulation of monocytes and lymphocytes within the glomerulus. In the present study, we examined whether the ambient glucose concentration alters the expression of MCP-1 and its receptor CCR2 in primary human mesangial cells (HMC).

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