Open AccessDifferential Expression of Mcp-1 and Its Receptor CCR2 in Glucose Primed Human Mesangial Cells
Author(s) -
Ulf Janssen,
Eveline Sowa,
Petra Marchand,
Jürgen Floege,
Aled Owain Phillips,
Heinfried H. Radeke
Publication year - 2002
Publication title -
the nephron journals/nephron journals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.951
H-Index - 72
eISSN - 2235-3186
pISSN - 1660-8151
DOI - 10.1159/000065448
Subject(s) - ccr2 , medicine , endocrinology , monocyte , proinflammatory cytokine , chemokine , receptor , chemokine receptor , biology , inflammation
Glomerular mononuclear cell infiltration is associated with the development of a diffuse glomerulosclerosis in patients with diabetic nephropathy. Monocyte chemoattractant protein-1 (MCP-1) plays an important role in the recruitment and accumulation of monocytes and lymphocytes within the glomerulus. In the present study, we examined whether the ambient glucose concentration alters the expression of MCP-1 and its receptor CCR2 in primary human mesangial cells (HMC).