Open AccessAnticoagulant Venom and Mammalian Secreted Phospholipases A<sub>2</sub>: Protein- versus Phospholipid-Dependent Mechanism of Action
Author(s) -
Carine Mounier,
Cassian Bon,
R. Manjunatha Kini
Publication year - 2001
Publication title -
pathophysiology of haemostasis and thrombosis
Language(s) - English
Resource type - Journals
eISSN - 1424-8840
pISSN - 1424-8832
DOI - 10.1159/000048074
Subject(s) - venom , phospholipid , snake venom , mechanism of action , phospholipase , phospholipase a2 , coagulation , chemistry , biochemistry , biology , microbiology and biotechnology , medicine , enzyme , in vitro , membrane
Some venom and mammalian-secreted phospholipases A(2) (sPLA(2)) have been described to exert an anticoagulant effect. This review will discuss and compare phospholipid-dependent versus protein-dependent mechanisms of action of these sPLA(2) on the coagulation cascade. The importance of venom proteins, and of the study of their pharmacological effects, to explore the physiological functions of homologous mammalian proteins is also pointed out.