Open AccessChanges in Haemostasis after Laparoscopic Surgery in Gynaecology: Contribution of the Thrombin Generation Test
Author(s) -
G. Freyburger,
Maureen Dubreuil,
A Audebert,
Sylvie Labrouche,
J.C. Pistre,
I Molinari,
F Dubecq,
Christian Laville,
X. Villanove
Publication year - 2001
Publication title -
pathophysiology of haemostasis and thrombosis
Language(s) - English
Resource type - Journals
eISSN - 1424-8840
pISSN - 1424-8832
DOI - 10.1159/000048042
Subject(s) - medicine , thrombosis , thrombin generation , surgery , laparoscopic surgery , hemostasis , thrombin , platelet , laparoscopy
Surgery induces immediate hypercoagulability by direct alteration of the vascular bed, release of procoagulant substances from the extravascular spaces and blood flow decrease, and delayed hypercoagulation in response to tissue damage which triggers inflammatory responses. Thus, the postoperative period represents a high-risk time for thrombosis. Recognition of high-risk individuals would make it possible to improve thromboembolism prevention. We studied in women undergoing laparoscopic surgery a series of markers known to be related to the thrombotic risk and confronted their results with those of a global test, the thrombin generation test (TGT) described by Hemker's group. Our results show that two groups of patients can be distinguished according to usual risk markers (PAI-1, TAT, body mass index): the higher risk group demonstrates higher initial TGT values, but also a postoperative decrease of the TGT values whose mechanisms remain to be defined.