Patchwork Cancer Predisposition | Zendy

L. Alexander Liggett | Zendy; Vijay G. Sankaran | Zendy

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Patchwork Cancer Predisposition

Author(s) -

L. Alexander Liggett,

Vijay G. Sankaran

Publication year - 2022

Publication title -

cancer discovery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.795

H-Index - 163

eISSN - 2159-8290

pISSN - 2159-8274

DOI - 10.1158/2159-8290.cd-22-0025

Subject(s) - genetic predisposition , cancer , germline , genetics , biology , allele , germline mutation , mosaic , mutation , computational biology , gene , history , archaeology

Summary: Inherited genetic variation is increasingly identified as an important predisposing factor to a variety of cancers. In this issue of Cancer Discovery, Pareja and colleagues developed a method of reliably detecting mosaic cancer susceptibility mutations in patients who have been sequenced as part of the MSK-IMPACT tumor profiling platform. This led to the identification of a number of mosaic mutations in cancer susceptibility alleles that are generally found in the germline, suggesting that many predisposition variants may be missed through conventional testing. See related article by Pareja et al., p. 949 (6).

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