Open AccessTrying for a BRAF Slam Dunk
Author(s) -
Antoni Ribas,
Roger S. Lo
Publication year - 2020
Publication title -
cancer discovery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.795
H-Index - 163
eISSN - 2159-8290
pISSN - 2159-8274
DOI - 10.1158/2159-8290.cd-20-0231
Subject(s) - computational biology , computer science , virology , biology
The first basket clinical trial testing the BRAF inhibitor vemurafenib resulted in evidence of activity in 13 unique cancer types with BRAF V600 mutations, but the response rates were variable. Therefore, different cancer histologies with the same driver oncogene display different degrees of oncogenic pathway addiction. See related article by Subbiah et al., p. 657 .
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