Open AccessAbstract PS6-55: The prognostic utility of AR/ER ratio in young women with breast cancer
Author(s) -
Jyothi S Prabhu,
Aruna Korlimarla,
Savitha Rajarajan,
A. Alexander,
C. E. Anupama,
Rakesh Ramesh,
B S Srinath,
T.S. Sridhar
Publication year - 2021
Publication title -
cancer research
Language(s) - English
Resource type - Conference proceedings
SCImago Journal Rank - 4.103
H-Index - 449
eISSN - 1538-7445
pISSN - 0008-5472
DOI - 10.1158/1538-7445.sabcs20-ps6-55
Subject(s) - breast cancer , medicine , estrogen receptor , context (archaeology) , cancer , androgen receptor , oncology , estrogen , hormone receptor , progesterone receptor , cohort , gynecology , biology , prostate cancer , paleontology
World over, less than a quarter of breast cancer diagnoses are in premenopausal women. However, in India premenopausal women constitute half of all women with breast cancer in most hospital case series. Most of these women present at advanced stages with aggressive subtypes of disease and hence the high mortality.The role and utility of detecting androgen receptor (AR) expression in the different sub-types of breast cancer, especially the ones without hormone receptor expression is yet to be firmly established. Evidence from previous studies is suggestive of its beneficial role in hormone receptor positive (HR+) breast cancer. The biological function of AR on the mammary epithelium is determined by the Estrogen receptor (ER) context, in that, it is found to be anti-proliferative in ER positive tumors while it is thought to promote growth in the absence of ER activity. An interesting approach to representing this interplay is as a ratio between AR/ER expressions. As expected, the ratio has been shown to be positively correlated with better outcomes in hormone receptor cancers, mostly in postmenopausal women. The effect of a high ratio in ER negative tumors seems more complicated. In this study, we have evaluated the AR/ER ratio specifically in patients younger than 50 years in whom the estrogenic influence is dominant due to their premenopausal status.