Open AccessAbstract 109: Myeloid Syk-PI3Kg-HIF axis inhibits anti-tumor adaptive immunity: In silico design of a “first in class” novel dual-Syk/PI3K inhibitor, SRX3207, to block the immunosuppressive tumor microenvironment
Author(s) -
Shweta Joshi,
Kevin Liu,
Muamera Zulcic,
Abhishek Singh,
Timothy Pham,
Christopher K. Glass,
Andrew B. Sharabi,
Guillermo Morales,
Joseph R. Garlich,
Donald L. Durden
Publication year - 2019
Publication title -
cancer research
Language(s) - English
Resource type - Conference proceedings
SCImago Journal Rank - 1.055
H-Index - 84
eISSN - 1538-7445
pISSN - 0008-5472
DOI - 10.1158/1538-7445.am2019-109
Subject(s) - syk , cancer research , macrophage polarization , tumor microenvironment , immune system , pi3k/akt/mtor pathway , pten , acquired immune system , biology , immunology , immunosuppression , macrophage , tyrosine kinase , microbiology and biotechnology , signal transduction , in vitro , biochemistry