Open AccessAbstract 104: Mechanistic insights and dose optimization for AZD3458, a novel selective PI3Kg immuno-modulator, using a quantitative systems approach
Author(s) -
Pablo Morentin Gutierrez,
Yuri Kosinsky,
Kirill Peskov,
Ivan Azarov,
Lulu Chu,
Veronika Voronova,
Martin Johnson,
Yingxue Chen,
Larissa S. Carnevalli,
Danielle Carroll,
Michele Moschetta,
Teresa Klinowska,
Gabriel Helmlinger
Publication year - 2019
Publication title -
cancer research
Language(s) - English
Resource type - Conference proceedings
eISSN - 1538-7445
pISSN - 0008-5472
DOI - 10.1158/1538-7445.am2019-104
Subject(s) - tumor microenvironment , cancer research , pi3k/akt/mtor pathway , cytotoxic t cell , population , immune system , t cell , flow cytometry , systems pharmacology , chemistry , biology , pharmacology , immunology , medicine , signal transduction , microbiology and biotechnology , in vitro , drug , biochemistry , environmental health