Open AccessTSPO-targeted PET and Optical Probes for the Detection and Localization of Premalignant and Malignant Pancreatic Lesions
Author(s) -
Allison S. Cohen,
Jun Li,
Matthew R. Hight,
Elliot T McKinley,
Allie Fu,
Adria Payne,
Yang Liu,
Dawei Zhang,
Qing Xie,
Mingfeng Bai,
Gregory D. Ayers,
Mohammed Noor Tantawy,
Jarrod A. Smith,
Frank Revetta,
M. Kay Washington,
Chanjuan Shi,
Nipun B. Merchant,
H. Charles Manning
Publication year - 2020
Publication title -
clinical cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.427
H-Index - 324
eISSN - 1557-3265
pISSN - 1078-0432
DOI - 10.1158/1078-0432.ccr-20-1214
Subject(s) - pancreatic intraepithelial neoplasia , medicine , pancreatic cancer , translocator protein , pathology , pancreas , asymptomatic , cancer , positron emission tomography , kras , radiology , cancer research , disease , pancreatic ductal adenocarcinoma , colorectal cancer , neuroinflammation
Pancreatic cancer is among the most aggressive malignancies and is rarely discovered early. However, pancreatic "incidentalomas," particularly cysts, are frequently identified in asymptomatic patients through anatomic imaging for unrelated causes. Accurate determination of the malignant potential of cystic lesions could lead to life-saving surgery or spare patients with indolent disease undue risk. Current risk assessment of pancreatic cysts requires invasive sampling, with attendant morbidity and sampling errors. Here, we sought to identify imaging biomarkers of high-risk pancreatic cancer precursor lesions.