Open AccessHLA Genotyping in Synovial Sarcoma: Identifying HLA-A*02 and Its Association with Clinical Outcome
Author(s) -
Evan Rosenbaum,
Kenneth Seier,
Chaitanya Bandlamudi,
Mark A. Dickson,
Mrinal M. Gounder,
Mary Lou Keohan,
Ping Chi,
Ciara M. Kelly,
Sujana Movva,
Benjamin A. Nacev,
Noemi Simeone,
Mark T.A. Donoghue,
Emily K. Slotkin,
LiXuan Qin,
Cristina R. Antonescu,
William D. Tap,
Sandra P. D’Angelo
Publication year - 2020
Publication title -
clinical cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.427
H-Index - 324
eISSN - 1557-3265
pISSN - 1078-0432
DOI - 10.1158/1078-0432.ccr-20-0832
Subject(s) - human leukocyte antigen , oncology , medicine , loss of heterozygosity , genotyping , genotype , allele , immunology , biology , genetics , gene , antigen
To determine if a targeted exome panel utilizing matched normal DNA can accurately detect germline and somatic HLA genes in patients with synovial sarcoma (SS) and whether select HLA-A*02 genotypes are prognostic or predictive of outcome in metastatic SS.