Open AccessThe Proteomic Landscape of Pancreatic Ductal Adenocarcinoma Liver Metastases Identifies Molecular Subtypes and Associations with Clinical Response
Author(s) -
Henry C.-H. Law,
Dragana Lagundžin,
Emalie J. Clement,
Fangfang Qiao,
Zachary S. Wagner,
Kimiko L. Krieger,
Diane Costanzo-Garvey,
Thomas C. Caffrey,
Jean L. Grem,
Dominick J. DiMaio,
Paul M. Grandgenett,
Leah M. Cook,
Kurt W. Fisher,
Fang Yu,
Michael A. Hollingsworth,
Nicholas T. Woods
Publication year - 2020
Publication title -
clinical cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.427
H-Index - 324
eISSN - 1557-3265
pISSN - 1078-0432
DOI - 10.1158/1078-0432.ccr-19-1496
Subject(s) - cancer research , proteomics , biology , progenitor cell , adenocarcinoma , proteome , medicine , oncology , bioinformatics , cancer , gene , stem cell , biochemistry , genetics
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease that can be separated into distinct subtypes based on molecular signatures. Identifying PDAC subtype-specific therapeutic vulnerabilities is necessary to develop precision medicine approaches to treat PDAC.