Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation
Author(s) -
Chao Liu,
Sayed H. Sadat,
Koji Ebisumoto,
Akihiro Sakai,
Bharat Panuganti,
Shuling Ren,
Yusuke Goto,
Sunny Haft,
Takahito Fukusumi,
Mizuo Ando,
Yuki Saito,
Theresa Guo,
Pablo Tamayo,
Huwate Yeerna,
William Kim,
Jacqueline A. Hubbard,
Andrew B. Sharabi,
J. Silvio Gutkind,
Joseph A. Califano
Publication year - 2020
Publication title -
clinical cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.427
H-Index - 324
eISSN - 1557-3265
pISSN - 1078-0432
DOI - 10.1158/1078-0432.ccr-18-3301
Subject(s) - head and neck squamous cell carcinoma , cancer research , gene knockdown , cannabinoid receptor , mapk/erk pathway , cell growth , small hairpin rna , cannabinoid , apoptosis , biology , cancer , medicine , oncology , head and neck cancer , receptor , signal transduction , antagonist , microbiology and biotechnology , genetics
Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is associated with daily marijuana use and is also increasing in parallel with increased marijuana use in the United States. Our study is designed to define the interaction between cannabinoids and HPV-positive HNSCC.
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