Open AccessDensity of CD3+ and CD8+ Cells in the Microenvironment of Colorectal Cancer according to Prediagnostic Physical Activity
Author(s) -
David Renman,
Björn Gylling,
Linda Vidman,
Stina Bodén,
Karin Strigård,
Richard Palmqvist,
Sophia Harlid,
Ulf Gunnarsson,
Bethany Van Guelpen
Publication year - 2021
Publication title -
cancer epidemiology, biomarkers and prevention
Language(s) - English
Resource type - Journals
eISSN - 1538-7755
pISSN - 1055-9965
DOI - 10.1158/1055-9965.epi-21-0508
Subject(s) - colorectal cancer , tumor microenvironment , medicine , immune system , cytotoxic t cell , cd8 , oncology , odds ratio , tumor infiltrating lymphocytes , confounding , population , cancer , immunology , biology , environmental health , biochemistry , in vitro
Physical activity is associated not only with a decreased risk of developing colorectal cancer but also with improved survival. One putative mechanism is the infiltration of immune cells in the tumor microenvironment. Experimental findings suggest that physical activity may mobilize immune cells to the tumor. We hypothesized that higher levels of physical activity prior to colorectal cancer diagnosis are associated with higher densities of tumor-infiltrating T-lymphocytes in colorectal cancer patients.