Open AccessInvestigation of the Interplay between Circulating Lipids and IGF-I and Relevance to Breast Cancer Risk: An Observational and Mendelian Randomization Study
Author(s) -
Vanessa Tan,
Caroline J. Bull,
Kalina Biernacka,
Alexander Teumer,
Tom G Richardson,
Eleanor Sanderson,
Laura J Corbin,
Tom Dudding,
Qibin Qi,
Robert C. Kaplan,
Jerome I. Rotter,
Nele Friedrich,
Uwe Völker,
Julia Mayerle,
Claire M. Perks,
Jeff M.P. Holly,
Nicholas J. Timpson
Publication year - 2021
Publication title -
cancer epidemiology, biomarkers and prevention
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.234
H-Index - 192
eISSN - 1538-7755
pISSN - 1055-9965
DOI - 10.1158/1055-9965.epi-21-0315
Subject(s) - mendelian randomization , breast cancer , medicine , cancer , observational study , oncology , confidence interval , endocrinology , lipoprotein , cholesterol , biology , genetics , genetic variants , gene , genotype
Circulating lipids and insulin-like growth factor 1 (IGF-I) have been reliably associated with breast cancer. Observational studies suggest an interplay between lipids and IGF-I, however, whether these relationships are causal and if pathways from these phenotypes to breast cancer overlap is unclear.