Open AccessReplication and Genetic Risk Score Analysis for Pancreatic Cancer in a Diverse Multiethnic Population
Author(s) -
David Bogumil,
David V. Conti,
Xin Sheng,
Lucy Xia,
XiaoOu Shu,
Stephen J. Pandol,
William J. Blot,
Zheng Wang,
Loı̈c Le Marchand,
Christopher A. Haiman,
Veronica Wendy Setiawan
Publication year - 2020
Publication title -
cancer epidemiology, biomarkers and prevention
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.234
H-Index - 192
eISSN - 1538-7755
pISSN - 1055-9965
DOI - 10.1158/1055-9965.epi-20-0963
Subject(s) - genome wide association study , single nucleotide polymorphism , pancreatic cancer , population , oncology , medicine , genetic association , snp , cancer , biology , genetics , genotype , gene , environmental health
Genome-wide association studies (GWAS) have identified several SNPs associated with pancreatic cancer. No studies yet have attempted to replicate these SNPs in US minority populations. We aimed to replicate the associations of 31 GWAS-identified SNPs with pancreatic cancer and build and test a polygenic risk score (PRS) for pancreatic cancer in an ethnically diverse population.