Diagnostic and Prognostic Value of Long Noncoding RNAs as Potential Novel Biomarkers in Intrahepatic Cholestasis of Pregnancy | Zendy

Shaohan Zou | Zendy; Shaojie Zhao | Zendy; Jing Wang | Zendy; Ruirui Dong | Zendy; Ping Zou | Zendy; Fengbing Liang | Zendy; Ting Zhu | Zendy; Tao Zhou | Zendy; Na Li | Zendy; Yan Zhang | Zendy; Tiejun Wang | Zendy; Minjian Chen | Zendy; Conghua Zhou | Zendy; Ting Zhang | Zendy; Liang Luo | Zendy

Open Access

Diagnostic and Prognostic Value of Long Noncoding RNAs as Potential Novel Biomarkers in Intrahepatic Cholestasis of Pregnancy

Author(s) -

Shaohan Zou,

Shaojie Zhao,

Jing Wang,

Ruirui Dong,

Ping Zou,

Fengbing Liang,

Ting Zhu,

Tao Zhou,

Na Li,

Yan Zhang,

Tiejun Wang,

Minjian Chen,

Conghua Zhou,

Ting Zhang,

Liang Luo

Publication year - 2021

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2021/8858326

Subject(s) - cholestasis of pregnancy , downregulation and upregulation , long non coding rna , pathological , cholestasis , microarray , oxidative stress , biomarker , biology , bioinformatics , apoptosis , cell cycle , cell , pregnancy , cancer research , medicine , fetus , endocrinology , gene expression , gene , genetics

Long noncoding RNAs (lncRNAs) are a class of important regulators participating in various pathological processes. Until now, the role of lncRNAs in the occurrence and development of intrahepatic cholestasis of pregnancy (ICP) has rarely been investigated. The data from microarray screening revealed 58 upregulated and 85 downregulated lncRNAs and 47 upregulated and 71 downregulated mRNAs in ICP patients compared to healthy controls. Bioinformatics analysis revealed biological processes focused on lipid metabolism, apoptosis, cell cycle, cell differentiation, and oxidative stress. Furthermore, the expressions of three lncRNAs (ENST505175.1, ASO3480, and ENST449605.1) chosen for verification were significantly decreased and showed the diagnostic and prognostic value for ICP based on ROC analysis. This is the first study to report the specific role of lncRNAs in ICP, which may be helpful for the diagnosis and prognosis of ICP clinically.

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