Hormone Replacement Therapy and Aging: A Potential Therapeutic Approach for Age-Related Oxidative Stress and Cardiac Remodeling | Zendy

Renáta Szabó | Zendy; Alexandra Hoffmann | Zendy; Denise Börzsei | Zendy; Krisztina Kupai | Zendy; Médea Veszelka | Zendy; A. Berkó | Zendy; Imre Pávó | Zendy; Rudolf Gesztelyi | Zendy; Béla Juhász | Zendy; Zsolt Turcsán | Zendy; Anikó Pósa | Zendy; Csaba Varga | Zendy

Open Access

Hormone Replacement Therapy and Aging: A Potential Therapeutic Approach for Age-Related Oxidative Stress and Cardiac Remodeling

Author(s) -

Renáta Szabó,

Alexandra Hoffmann,

Denise Börzsei,

Krisztina Kupai,

Médea Veszelka,

A. Berkó,

Imre Pávó,

Rudolf Gesztelyi,

Béla Juhász,

Zsolt Turcsán,

Anikó Pósa,

Csaba Varga

Publication year - 2021

Publication title -

oxidative medicine and cellular longevity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.494

H-Index - 93

eISSN - 1942-0900

pISSN - 1942-0994

DOI - 10.1155/2021/8364297

Subject(s) - oxidative stress , hormone replacement therapy (female to male) , medicine , hormone therapy , ventricular remodeling , therapeutic approach , bioinformatics , cardiology , biology , heart failure , disease , cancer , testosterone (patch) , breast cancer

Advanced age is an independent risk factor for cardiovascular diseases, which might be further exacerbated by estrogen deficiency. Hormone replacement therapy (HRT) decreases cardiovascular risks and events in postmenopausal women; however, its effects are not fully elucidated in older individuals. Thus, the aim of our study is to examine the impact of HRT on oxidant/antioxidant homeostasis and cardiac remodeling. In our experiment, control (fertile) and aging (~20-month-old) female Wistar rats were used. Aging rats were further divided into estrogen- (E 2 , 0.1 mg/kg/day per os ) or raloxifene- (RAL, 1.0 mg/kg/day per os ) treated subgroups. After 2 weeks of treatment, cardiac heme oxygenase (HO) activity, total glutathione (GSH) content, matrix metalloproteinase-2 (MMP-2) activity, and the concentrations of collagen type I and tissue inhibitor of metalloproteinase (TIMP-2), as well as the infarct size, were determined. The aging process significantly decreased the antioxidant HO activity and GSH content, altered the MMP-2/TIMP-2 signaling, and resulted in an excessive collagen accumulation, which culminated in cardiovascular injury. However, 2 weeks of either E 2 or RAL treatment enhanced the antioxidant defense mechanisms and attenuated cardiac remodeling related to aging. Our findings clearly show that 2-week-long HRT is a potential intervention to bias successful cardiovascular aging via reducing oxidative damage and cardiovascular dysfunction.

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