z-logo
open-access-imgOpen Access
Role of Intestinal Microbiota on Gut Homeostasis and Rheumatoid Arthritis
Author(s) -
Mingxin Li,
Fang Wang
Publication year - 2021
Publication title -
journal of immunology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.315
H-Index - 83
eISSN - 2314-8861
pISSN - 2314-7156
DOI - 10.1155/2021/8167283
Subject(s) - dysbiosis , immunology , immune system , rheumatoid arthritis , pathogenesis , gut flora , population , inflammation , gastrointestinal tract , inflammatory bowel disease , disease , autoimmune disease , mucosal immunology , medicine , biology , immunity , antibody , environmental health
Rheumatoid arthritis (RA) is a chronic inflammatory disease that is immune mediated. Patients typically present with synovial inflammation, which gradually deteriorates to investigate severe cartilage and bone damage, affecting an individual's ability to perform basic tasks and impairing the quality of life. When evaluated against healthy controls, patients with RA have notable variations within the constituents of the gut microbiota. The human gastrointestinal tract mucosa is colonized by trillions of commensal microbacteria, which are key actors in the initiation, upkeep, and operation of the host immune system. Gut microbiota dysbiosis can adversely influence the immune system both locally and throughout the host, thus predisposing the host to a number of pathologies, including RA. Proximal intestinal immunomodulatory cells, situated in specific locales within the intestine, are a promising intermediary through which the gastrointestinal microbiota can influence the pathogenesis and progression of RA. In the early stages of the disease, the microbiota appear to differ from those present in healthy controls. This difference may reflect potential autoimmune mechanisms. Research studies evaluating intestinal microbiota have demonstrated that RA is associated with a bacterial population growth or with a decline when judged against control groups. The aim of this review is to examine the studies that connect intestinal dysbiosis with the autoimmune pathways implicated in the pathogenesis of RA.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here