Expression of Tspan8 in Patients with Intrahepatic Cholangiocarcinoma and Its Relationship with Clinicopathological Features and Prognosis | Zendy

Zhenhua Tan | Zendy; Renrui Wan | Zendy; Minzhi Chen | Zendy; Ping Xie | Zendy; Li Peng | Zendy; Yan Shen | Zendy; Zhiping Pan | Zendy; Hai Qian | Zendy

Open Access

Expression of Tspan8 in Patients with Intrahepatic Cholangiocarcinoma and Its Relationship with Clinicopathological Features and Prognosis

Author(s) -

Zhenhua Tan,

Renrui Wan,

Minzhi Chen,

Ping Xie,

Li Peng,

Yan Shen,

Zhiping Pan,

Hai Qian

Publication year - 2021

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2021/7475938

Subject(s) - intrahepatic cholangiocarcinoma , stage (stratigraphy) , pathological , medicine , metastasis , logistic regression , incidence (geometry) , pathology , lymph node metastasis , oncology , clinical significance , gastroenterology , cancer , biology , paleontology , physics , optics

The incidence and mortality of intrahepatic cholangiocarcinoma (ICC) are increasing worldwide. High invasion and metastasis are one of the main causes of death in patients. The selection of reasonable and effective molecular markers to evaluate the prognosis of patients with ICC has important clinical guiding significance. In this study, the expression of Tspan protein in ICC and normal tissues was compared, the correlation between Tspan expression and pathological features of patients was analyzed by the logistic regression model using multivariate analysis, and the relationship between Tspan8 expression and prognosis of ICC patients was analyzed by the Kaplan–Meier survival curve. The results showed that Tspan8 is highly positive in ICC tissues, TNM stage, degree of tumor differentiation, lymph node metastasis, and Tspan8 protein expression were independently correlated, and the overexpression of Tspan was associated with the prognosis of ICC invasion and metastasis. This provides a new idea for clinical treatment.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research