Metabolomic Study of Zuojin Pill in Relieving 1-Methyl-3-nitro-1-nitrosoguanidine-Induced Chronic Atrophic Gastritis | Zendy

Yuling Tong | Zendy; Manyi Jing | Zendy; Xu Zhao | Zendy; Honghong Liu | Zendy; Shizhang Wei | Zendy; Ruisheng Li | Zendy; Xia Liu | Zendy; Min Wang | Zendy; Hongtao Song | Zendy; Yanling Zhao | Zendy

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Metabolomic Study of Zuojin Pill in Relieving 1-Methyl-3-nitro-1-nitrosoguanidine-Induced Chronic Atrophic Gastritis

Author(s) -

Yuling Tong,

Manyi Jing,

Xu Zhao,

Honghong Liu,

Shizhang Wei,

Ruisheng Li,

Xia Liu,

Min Wang,

Hongtao Song,

Yanling Zhao

Publication year - 2021

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2021/7004798

Subject(s) - atrophic gastritis , metabolomics , medicine , mechanism (biology) , traditional chinese medicine , inflammation , proinflammatory cytokine , pathological , pharmacology , clinical significance , sulindac , pill , gastritis , bioinformatics , nonsteroidal , helicobacter pylori , biology , pathology , philosophy , alternative medicine , epistemology

The classic prescription Zuojin Pill (ZJP) shows a good therapeutic effect on chronic atrophic gastritis (CAG); it is of great significance to clarify its specific mechanism. Therefore, we explore the mechanism of ZJP on MNNG-induced CAG by integrating approaches. First of all, through the pathological changes of gastric tissue and the expression level of PGI and PGI/II in serum, the expression of inflammation-related factors was determined by RT-PCR to determine the efficacy. Then, UPLC-Q-TOF/MS was used for plasma and urine metabolomic analysis to screen the specific potential biomarkers and metabolic pathway of ZJP in ameliorating CAG and to explore its possible mechanism. ZJP significantly ameliorate the pathological injury of gastric tissue, increase levels of PGI and PGI/II, and reduce the expression level of proinflammatory factors. Through metabolomic analysis, 9 potential metabolic differences were identified and 6 related metabolic pathways were enriched. These findings indicate for the first time the potential mechanism of ZJP in improving CAG induced by MNNG and are of great significance to the clinical development and application of ZJP-related drugs.

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