Open Accessmir-182-5p Regulates Cell Growth of Liver Cancer via Targeting RCAN1
Author(s) -
Jianxing Zheng,
Dongyang Wu,
Libing Wang,
Fengzhi Qu,
Daming Cheng,
Xiaogang Liu
Publication year - 2021
Publication title -
gastroenterology research and practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 45
eISSN - 1687-630X
pISSN - 1687-6121
DOI - 10.1155/2021/6691305
Subject(s) - regulator , downregulation and upregulation , liver cancer , cell growth , medicine , cancer , cancer research , cancer cell , cell , cell cycle , biomarker , mechanism (biology) , biology , biochemistry , gene , philosophy , epistemology
Regulator of calcineurin 1 (RCAN1) is an endogenous protein that is involved in the regulation of the occurrence and progression of a variety of cancers, but currently, people know little about its potential mechanism. This study investigated the function and mechanism of RCAN1 and miR-182-5p in liver cancer cells. In this study, reliable data demonstrated that RCAN1 suppressed cell proliferation, migration, invasion, and cell cycle progression of liver cancer. Additionally, the expression of RCAN1 was noted to be regulated by its upstream regulator miR-182-5p, and miR-182-5p was prominently highly expressed in liver cancer cells. Based on this, it was further proved through cell experiments that miR-182-5p facilitated cell growth of liver cancer through RCAN1 downregulation, showing that RCAN1 may be a fresh biomarker and target for diagnosis and treatment of liver cancer.