Open AccessFrom TTP to Glomerulonephritis: A Lifetime of Lupus
Author(s) -
Fadi Kharouf,
Sigal Shahar,
Yoav Hershkovitz,
Shaheen Alaa,
Areej Bayatra,
Asa Kessler,
Yuval Ishay
Publication year - 2021
Publication title -
case reports in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.2
H-Index - 20
eISSN - 1687-9627
pISSN - 1687-9635
DOI - 10.1155/2021/6654748
Subject(s) - medicine , pancytopenia , immunosuppression , dermatology , rash , constitutional symptoms , thrombotic thrombocytopenic purpura , malar rash , systemic lupus erythematosus , immunology , disease , bone marrow , anti nuclear antibody , autoantibody , antibody , platelet
We report the case of a 56-year-old male patient, who over two decades, sequentially presented with a combination of clinical manifestations. These included thrombotic thrombocytopenic purpura (TTP), right leg deep vein thrombosis (DVT), and eventually constitutional symptoms, arthralgia, diffuse lymphadenopathy, pancytopenia, skin rash, pericarditis, and glomerulonephritis. Serologic tests and renal pathology uncovered a diagnosis of systemic lupus erythematosus (SLE), and immunosuppressive therapy was initiated. Soon after, the patient developed striking cytomegalovirus (CMV) viremia, requiring prolonged antiviral therapy and reduction of immunosuppression. Finally, an acute embolic stroke complicated the disease course. Prompt interventions allowed an excellent clinical outcome.