Clinical and Antimicrobial Evaluation of Copaifera langsdorffii Desf. Dental Varnish in Children: A Clinical Study | Zendy

Lídia Audrey Rocha Valadas | Zendy; Patrícia Leal Dantas Lobo | Zendy; Said Gonçalves da Cruz Fonseca | Zendy; Francisco Vagnaldo Fechine | Zendy; Edílson Martins Rodrigues Neto | Zendy; Marta Maria de França Fonteles | Zendy; Lorena Ribeiro de Aguiar Trévia | Zendy; Hilda Lara Prado Vasconcelos | Zendy; Sandra Mara da Silva Lima | Zendy; Mara Assef Leitão Lotif | Zendy; Analice Mendes Barreto Fernandes | Zendy; Mary Anne Medeiros Bandeira | Zendy

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Clinical and Antimicrobial Evaluation of Copaifera langsdorffii Desf. Dental Varnish in Children: A Clinical Study

Author(s) -

Lídia Audrey Rocha Valadas,

Patrícia Leal Dantas Lobo,

Said Gonçalves da Cruz Fonseca,

Francisco Vagnaldo Fechine,

Edílson Martins Rodrigues Neto,

Marta Maria de França Fonteles,

Lorena Ribeiro de Aguiar Trévia,

Hilda Lara Prado Vasconcelos,

Sandra Mara da Silva Lima,

Mara Assef Leitão Lotif,

Analice Mendes Barreto Fernandes,

Mary Anne Medeiros Bandeira

Publication year - 2021

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2021/6647849

Subject(s) - antimicrobial , fluoride varnish , traditional medicine , dentistry , varnish , medicine , biology , materials science , microbiology and biotechnology , nanotechnology , coating

Background The objective of this study was to evaluate the clinical and microbiological efficacies of ( C. langsdorffii ) dental varnish in children at high risk of dental caries..Methods This is a longitudinal, randomized, controlled clinical trial. Ninety high-risk caries-free children (ICDAS II = 0) were recruited and randomly divided into three groups: C. langsdorffii , chlorhexidine, or fluoride. The varnishes were applied on the second deciduous molars for three times: baseline (D0), after 90 days (D90), and after 180 days (D180). Saliva was collected on D0, D90, D180, and D360 to evaluate S. mutans reduction. Statistics were carried out by ANOVA, Tukey's test, and the paired t -test.Results Copaiba varnish demonstrated significant S. mutans reduction: D360 versus D0 ( p < 0.0001), D180 versus D0 ( p < 0.001), D360 versus D90 ( p < 0.001), D180 versus D90 ( p < 0.001), and D360 versus D180 ( p < 0.05). Chlorhexidine varnish significantly reduced S. mutans at D180 versus D0 ( p < 0.05). Fluoride reduced at D180 versus D0 ( p < 0.001).Conclusions Three annual applications of this varnish showed substantial antimicrobial activity against S. mutans and caries prevention for up to 12 months.

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