Open AccessEffective Antiplasmodial and Cytotoxic Activities of Synthesized Zinc Oxide Nanoparticles Using Rhazya stricta Leaf Extract
Author(s) -
Sanodia Najoom,
Fozia Fozia,
Ijaz Ahmad,
Abdul Wahab,
Nisar Ahmad,
Riaz Ullah,
Anadil Gul,
Ahmed Bari,
Muhammad Yahya Khan,
Anis A. Khan
Publication year - 2021
Publication title -
evidence-based complementary and alternative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.552
H-Index - 90
eISSN - 1741-4288
pISSN - 1741-427X
DOI - 10.1155/2021/5586740
Subject(s) - wurtzite crystal structure , fourier transform infrared spectroscopy , nuclear chemistry , nanoparticle , zinc , scanning electron microscope , absorption (acoustics) , materials science , absorption spectroscopy , infrared spectroscopy , analytical chemistry (journal) , chemistry , nanotechnology , chemical engineering , organic chemistry , physics , quantum mechanics , engineering , composite material
In the present study, zinc oxide (ZnO) nanoparticles were prepared using ZnCl 2 .2H 2 O as a precursor, via green route using leaf extract of Rhazya stricta as capping and reducing agent. The prepared ZnO nanoparticles were examined using UV-visible spectrophotometer (UV-Vis), Fourier transform infrared spectrometer (FT-IR), X-ray diffraction spectrometer (XRD), and scanning electron microscope (SEM). The UV-Vis absorption spectrum at 355 nm showed an absorption peak, which indicates the formation of ZnO NPs. The FT-IR spectra analysis was performed to identify the potential biomolecule of the as-prepared ZnO NPs. The FT-IR spectra showed peaks at 3455, 1438, 883, and 671 cm −1 in the region of 4000–500 cm −1 , which indicates –OH, NH, C-H, and M-O groups, respectively. The SEM images showed aggregation of ZnO nanoparticles with an average size of 70–90 nm. The XRD study indicated that the ZnO NPs were crystalline in nature with hexagonal wurtzite structure and broad peaks were observed at 2 theta positions 31.8°, 34.44°, 36.29°, 47.57°, 56.61°, 67.96°, and 69.07°. The synthesized ZnO NPs were found to be good antiplasmodial with a 50% inhibitory concentration (IC 50 ) value of 3.41 μ g/mL. It is concluded from the current study that the ZnO NPs exhibited noble antiplasmodial activity, and for the improvement of antiplasmodial medications, it might be used after further in vivo studies.