Open AccessOral Squamous Cell Carcinoma in a Patient with Fanconi Anemia
Author(s) -
Milla Huuhka,
Aaro Turunen
Publication year - 2021
Publication title -
case reports in dentistry/case reports in dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.221
H-Index - 11
eISSN - 2090-6447
pISSN - 2090-6455
DOI - 10.1155/2021/5571649
Subject(s) - medicine , fanconi anemia , bone marrow failure , basal cell , anemia , head and neck squamous cell carcinoma , oral mucosa , head and neck , genetic disorder , oncology , pathology , cancer research , dermatology , cancer , head and neck cancer , stem cell , surgery , gene , dna repair , haematopoiesis , biochemistry , chemistry , genetics , disease , biology
Fanconi anemia (FA) is a rare autosomal recessive genetic disorder characterized by different types of malformations, skin lesions, bone marrow failure, and increased risk for both hematological malignancies and solid tumors, especially head and neck squamous cell carcinomas (HNSCC). FA patients may also display a low tolerance to oncologic treatments. The authors present a case of mandibular squamous cell carcinoma in a young FA patient. Because of the aggressive nature of the SCC and complex treatment options, we recommend a strict lifelong follow-up for all FA patients to detect early changes in the oral mucosa.