Open AccessInfluence of Dietary Components and Traditional Chinese Medicine on Hypertension: A Potential Role for Gut Microbiota
Author(s) -
Guoxin Zhang,
Ling Jin,
Hua Jin,
Guisen Zheng
Publication year - 2021
Publication title -
evidence-based complementary and alternative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.552
H-Index - 90
eISSN - 1741-4288
pISSN - 1741-427X
DOI - 10.1155/2021/5563073
Subject(s) - gut flora , akkermansia , dysbiosis , bacteroides , firmicutes , bifidobacterium , bacteroidetes , disease , medicine , traditional chinese medicine , flora (microbiology) , biology , immunology , lactobacillus , pathology , alternative medicine , bacteria , genetics , 16s ribosomal rna
Hypertension (HTN) is an important worldwide public health issue affecting human health. The pathogenesis of HTN involves complex factors such as genetics, external environment, diet, and the gut microbial dysbiosis. The gut microbiota, as a medium of diet and drug metabolism, is closely correlated to host's health and disease (including HTN). Literatures were randomly collected from various databases including PubMed, ScienceDirect, Google Scholar, and China National Knowledge Infrastructure (CNKI). In this review, we elucidate the relationship between HTN and gut microbiota, as well as concerning the effects of different dietary components, diet-derived microbial metabolites, and traditional Chinese medicine (TCM) on intestinal flora. These studies have shown that diet and TCM can regulate and balance the intestinal flora, which are inclined to increasing the abundance of Akkermansia , Bifidobacterium , and Bacteroides and reducing the ratio of Firmicutes and Bacteroidetes . Moreover, monitoring the dynamic change of gut microflora may indicate patient prognosis and personalized response to treatment. This review aims to provide novel perspectives and potential personalized interventions for future HTN management from the perspective of gut microbiota.