Open AccessTechniques for Detection of Clinical Used Heparins
Author(s) -
Binjie Li,
Huimin Zhao,
Mingjia Yu
Publication year - 2021
Publication title -
international journal of analytical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.352
H-Index - 16
eISSN - 1687-8779
pISSN - 1687-8760
DOI - 10.1155/2021/5543460
Subject(s) - heparin , chondroitin sulfate , sulfation , chondroitin , anticoagulant , computer science , chemistry , medicine , glycosaminoglycan , biochemistry
Heparins and sulfated polysaccharides have been recognized as effective clinical anticoagulants for several decades. Heparins exhibit heterogeneity depending on the sources. Meanwhile, the adverse effect in the clinical uses and the adulteration of oversulfated chondroitin sulfate (OSCS) in heparins develop additional attention to analyze the purity of heparins. This review starts with the description of the classification, anticoagulant mechanism, clinical application of heparins and focuses on the existing methods of heparin analysis and detection including traditional detection methods, as well as new methods using fluorescence or gold nanomaterials as probes. The in-depth understanding of these techniques for the analysis of heparins will lay a foundation for the further development of novel methods for the detection of heparins.